PRRT and the promise it holds for cancer treatment

As we continue our conversation on Precision Medicine for cancer, a popular therapy used to treat NET tumours or Neuro Endocrine Tumours is PRRT or Peptide Receptor Radionuclide therapy.
Neuroendocrine tumours are a rare form of cancer and originate from Neuro endocrine cells in the body and hence the name.They are different from adenocarcinoma’s and often do not do not respond well to chemotherapy, the 1st line of treatment for most cancers.

By administering radioactive protein lutetium octreotate, it is possible to treat NET tumours or neuro endocrine carcinoma with precision and offset progression of disease.

PRRT for neuroendocrine tumour
PRRT treatment for metastatic cancer cells spreading and growing. Tailor-made precision medicine based on genetic profile and molecular structure of the tumour.

In PRRT a peptide or a cell targeting protein is combined with a small amount of radio active nuclide creating what is called as a radio peptide. The radio peptide when injected into the patients blood stream travels and binds to a neuro endocrine tumour, delivering a high dose of radiation to the tumours. This also limits damage to the nearby healthy tissue and hence lesser and milder side effects than chemotherapy.

What kind of cancers can be treated by PRRT?

Along with Neuroendocrine tumours, carcinoids, islet cell carcinoma of the pancreas, small cell carcinoma of the lung a form of lung cancer, pheochromocytoma (a rare tumor that forms in the adrenal glands), gastro-enteropancreatic (stomach cancer , intestine cancer and pancreas) neuroendocrine tumors, and rare thyroid cancers that are unresponsive to treatment with radio iodine are often treated with PRRT.

Role of PRRT is also being explored for treatment of prostate cancer.

When is a patient a candidate for PRRT ?

Patients with following conditions are often proposed for PRRT

  • When neuro endocrine tumours are not responsive to other lines of cancer treatment
  • When surgical removal of tumours is not possible at current stage, PRRT may be used to reduce size of the tumours.
  • PRRT is also a treatment option for last stage inoperable cancers when metastasis has set in.
    The main aim of PRRT is then to slow down progression of disease, offer relief and prolong life.

However, not all neuroendocrine tumours respond to PRRT. First an OctreoScan is done. If the patient is found to have a positive OctreoScan and meets other requirements, PRRT is proposed.

What happens during PRRT ?

For patients having a positive octreoscan, to start with an amino acid solution is delivered to protect the kidneys.

As most net tumours have a lot of a specific type of surface receptor, a protein called somatostatin. Octreotide, is a lab version of somastostatin. During PRRT, a dose of radio nuclides such as Lutetium, Yttrium are often combined with octreotide and injected into the blood stream.

Molecular imaging and scans follow to see whether the radio peptide has latched on of the tumour sites correctly.

The entire session usually lasts for about 4 hrs and is often done as an out patient procedure.

The main goals of PRRT hence are to provide symptom relief, to stop or slow tumor progression and to improve overall survival.

Advantages of PRRT ?

PRRT along with other molecular therapies or targeted therapies offer excellent results as they are tailor made keeping in mind molecular properties of the tumour and also biologic characteristics of the patient.

PRRT is offered in Germany , USA, UK and other developed countries at a significant cost, In India, a single session of PRRT costs approx USD 6300.

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Thyroid Cancer Symptoms and Treatment

Thyroid Cancer

The thyroid gland is present below the Adam’s in the front of the neck. It is a butterfly shaped organ. The thyroid gland produce hormones that regulate the body’s response to hot and cold senses, the energy level of the body, and weight and appetite.

Thyroid cancer in children is rare and often curable. Exposure to head and neck irradiation results in an increased risk. Only one in every 1,200 children under 20 are affected by thyroid cancer in the United States each year.

There is nearly 95%. survival rates among children.

Types of Thyroid Cancer:

Thyroid cancer is further divided into following four types.
1. Papillary thyroid carcinoma
2. Follicular thyroid carcinoma
3. Medullary thyroid carcinoma
4. Anaplastic thyroid carcinomas

Symptoms of Thyroid Cancer:
Sign and Symptoms include trouble breathing, trouble swallowing and changes in a child’s voice.

Thyroid Cancer Treatment:

Thyroid cancer is commonly treated by one or a combination of treatments such as Surgery, Hormonal therapy, Radioactive iodine (radioiodine) therapy, External-beam radiation therapy, Chemotherapy and Targeted therapy.

Thyroid Cancer, treatment, survival, and why to choose India.

Thyroid Cancer, treatment, survival, and why to choose IndiaThyroid Cancer Treatment:

The thyroid gland is one of the body’s primary producer of hormones, especially for factors controlling metabolism speed and efficiency. Located in the neck, close to the larynx, this gland can, like many other parts of the body, can be susceptible to diseases especially Cancer. According to global statistics, there are 56,000 new thyroid cancer victims in just the united states alone every year. The most common form is papillary thyroid cancer, and occurs most often in women and adults over the age of 30, but can affect anyone of any age. Thyroid cancer may be hard to detect as it remains unnoticed and displays few symptoms over the early lifetime of it’s development. In the elderly, however, it can be very aggressive. Commonly characterized by hoarse voice, neck pain, and enlarged lymph nodes. Most cases of Thyroid cancer begins when a person develops a nodule on the thyroid gland, and while most people will only have one, the chance of receiving the nodule increases with age. To our benefit, 99% of nodules are benign, however it can still be and should be examined properly.
Of the four types of cancer: Papillary Cancer , Follicular cancer, Medullary cancer, and Anaplastic cancer, Papillary dominates cancer cases by being the identified strain over 80% of the time. Thankfully, most cases, especially papillary cancer, are curable and in 97% of cases if treated properly and timely. In most cases the affected part of the thyroid is removed during a biopsy as the preferred treatment. Medullary is extremely rare in the case of thyroid cancer, but is more difficult to treat due to it’s fast pace of spreading. Just as well, Anaplastic cancer though rare, is incurable nonetheless.  Surgery followed by uptake of radioactive iodine is the ususal form of treatment.
As to where is the best area to receive competent and affordable treatment for Cancer, the home country you experience it in may not be your best option. The current prices in India, as found by globally available prices may be the most feasible option. It is suggested that people who feel they have concern towards thyroid cancer might first see an Oncologist or a specialist in the head and neck before pursuing a non-researched choice. Often times in India the checkup is available at a consultation of $20 and can be made easy and convenient with the proper insurance. Most practicing head and neck onco surgeons in India offer a total thyroidectomy for less than $7000, while treatment in the United states , Europe and the west may exceed  by $10000 in cost with ongoing treatment and hospital fees. The service of providing radioactive iodine, are also less expensive for the same medically practiced standards and qualifications. It may be that you are not located at the best place to receive treatment, or perhaps you are but you may not be able to afford it without assistance. New age healthcare advisory platforms such as ihealthkonnect help you discover prices across treatment options, surgeries and help you connect with hospitals across India and make informed, affordable healthcare decision.

 

So Search, compare and save on cost of thyroid cancer treatment in India , visit www.ihealthkonnect.com or write to us on info@ihealthkonnect.com or chat with us at m.me/ihealthkonnect