Sugar and cancer- Best Friends?

The question here really is ” Is there a link up between sugar and cancer? And if yes, is the scare for real ?
PET Scan, one of the best-known cancer detection tests, uses, radioactively labelled glucose to detect sugar hungry cancer cells.
 
While carrying out a PET CT scan, patients are made to drink radioactive glucose water. The radioactive glucose gets actively taken by glucose hungry cancer cells due to which the cancer cells light up. The well lit up cancer cells indicate spread of cancer or spread of cancer cells in various parts of the body.
PET Scan
PET Scan showing well lit cancer cells
As the test works on a cellular level, a PET Scan is the most accurate test for determining spread and growth of cancer.
Sugar basically feeds and fuels cancer cells here due to which the radioactive glucose get taken up, very quickly by the cancer cells in the body.
Research shows that the metabolism of cancer cells is very different from healthy cells. Cancer cells use a process called “Glycolysis” to fuel their growth and the uptake rate is over 10 times that of normal healthy cells.
This clearly means that sugar consumption is connected to cancer and any cancer treatment, must focus on total elimination of sugar in the diet.
Another reason for eliminating sugar is the release of insulin by our pancreas. Whenever we consume sugar, our pancreas release insulin. Insulin promotes cell growth. Breast tissue, for example, has insulin receptors and excess insulin promotes malignant cell growth putting women consuming excess sugar at double the risk of breast cancer and pancreatic cancer. For men, sugar consumption doubles their risk of prostate cancer.
Sugar also creates an acidic environment in the body, ideal for cancer cells to thrive beside suppressing the immune system response of the body.
Consuming 10 tsp of sugar can suppress phagocytes by almost 30% in the next 1 hr and then almost 50% in the following hour and it takes about 5 hrs each time for the body’s immune system to recover completely. Which means that with each glass of Orange Juice( typically 9 tsp of sugar), our immune system is suppressed for almost 5 hrs, which means decreased immunity or response to cancer cells while fuelling growth via glycolysis and increase in insulin.
Sugar consumption, especially in the middle and older years, therefore puts us at increased risk of developing cancer and is a total “NO” while on cancer treatment.
To connect to the best cancer doctors, in India, click here.
To get estimated cost of cancer treatment in India from, the top 10 cancer hospitals in India, send us a query or write to us on info@ihealthkonnect.com
To compare cost of cancer treatment from the best cancer hospitals in India, click here

PRRT and the promise it holds for cancer treatment

As we continue our conversation on Precision Medicine for cancer, a popular therapy used to treat NET tumours or Neuro Endocrine Tumours is PRRT or Peptide Receptor Radionuclide therapy.
Neuroendocrine tumours are a rare form of cancer and originate from Neuro endocrine cells in the body and hence the name.They are different from adenocarcinoma’s and often do not do not respond well to chemotherapy, the 1st line of treatment for most cancers.

By administering radioactive protein lutetium octreotate, it is possible to treat NET tumours or neuro endocrine carcinoma with precision and offset progression of disease.

PRRT for neuroendocrine tumour
PRRT treatment for metastatic cancer cells spreading and growing. Tailor-made precision medicine based on genetic profile and molecular structure of the tumour.

In PRRT a peptide or a cell targeting protein is combined with a small amount of radio active nuclide creating what is called as a radio peptide. The radio peptide when injected into the patients blood stream travels and binds to a neuro endocrine tumour, delivering a high dose of radiation to the tumours. This also limits damage to the nearby healthy tissue and hence lesser and milder side effects than chemotherapy.

What kind of cancers can be treated by PRRT?

Along with Neuroendocrine tumours, carcinoids, islet cell carcinoma of the pancreas, small cell carcinoma of the lung a form of lung cancer, pheochromocytoma (a rare tumor that forms in the adrenal glands), gastro-enteropancreatic (stomach cancer , intestine cancer and pancreas) neuroendocrine tumors, and rare thyroid cancers that are unresponsive to treatment with radio iodine are often treated with PRRT.

Role of PRRT is also being explored for treatment of prostate cancer.

When is a patient a candidate for PRRT ?

Patients with following conditions are often proposed for PRRT

  • When neuro endocrine tumours are not responsive to other lines of cancer treatment
  • When surgical removal of tumours is not possible at current stage, PRRT may be used to reduce size of the tumours.
  • PRRT is also a treatment option for last stage inoperable cancers when metastasis has set in.
    The main aim of PRRT is then to slow down progression of disease, offer relief and prolong life.

However, not all neuroendocrine tumours respond to PRRT. First an OctreoScan is done. If the patient is found to have a positive OctreoScan and meets other requirements, PRRT is proposed.

What happens during PRRT ?

For patients having a positive octreoscan, to start with an amino acid solution is delivered to protect the kidneys.

As most net tumours have a lot of a specific type of surface receptor, a protein called somatostatin. Octreotide, is a lab version of somastostatin. During PRRT, a dose of radio nuclides such as Lutetium, Yttrium are often combined with octreotide and injected into the blood stream.

Molecular imaging and scans follow to see whether the radio peptide has latched on of the tumour sites correctly.

The entire session usually lasts for about 4 hrs and is often done as an out patient procedure.

The main goals of PRRT hence are to provide symptom relief, to stop or slow tumor progression and to improve overall survival.

Advantages of PRRT ?

PRRT along with other molecular therapies or targeted therapies offer excellent results as they are tailor made keeping in mind molecular properties of the tumour and also biologic characteristics of the patient.

PRRT is offered in Germany , USA, UK and other developed countries at a significant cost, In India, a single session of PRRT costs approx USD 6300.

Get in touch with us for a second opinion on cancer treatment, write to us on info@ihealthkonnect.com or send us a query

To compare cost of cancer treatment in India, from some of the best hospitals, click here.

To chat with us on Facebook, click here.