Sickle Cell Anemia

sickel cell anemia,bone marrow transplantSickle Cell Disease (SCD) is the most common inherited disorder of haemoglobin worldwide and  affects nearly 100,000 people in the United States and is rampant in Africa

Every pregnancy carries 25% risk when both partners carry a sickle cell gene

Diagnosing Sickle Cell Anemia

HPLC or High-Performance Liquid Chromatography (HPLC) is the standard tests for diagnosing Sickle Cell Disease (SCD). The test separates different forms of proteins in a column and can detect mutant forms of hemoglobin.

What is  the treatment for sickle cell anemia?

Treatment choices for sickle cell anemia are the drug hydroxyurea and chronic red blood cell transfusions. These treatments may lessen the complications of sickle cell disease, but they do not cure the disease.

Bone Marrow Transplant is the only cure for sickle cell anemia treatment at this time. Transplants from matched related donors offer about an 85 percent chance of cure.

All sickle cell anemia patients do not need a  bone marrow transplant. However the younger the patient, the higher the chances of cure after a bone marrow transplant.

With age as organ damage increases, chances of a successful transplant decrease.

Indications for a transplant are

  • Frequent Pain
  • Stroke
  • Acute Chest Syndrome which means the patient suffers from pneumonia, frequent chest infections
  • Splenic  Sequestration which causes sudden and severe anemia, paleness, and the haemoglobin may actually drop to as low as 1-3g/dl   which may even result in shock and death within a few hours of onset.

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